Holly is filled with regret after eighteen years at home with her three children. She sheds sixty pounds and loses herself in the world of extramarital sex. Andrea is a single mom watching her friend Holly's meltdown with a mixture of concern and contempt. Holly is throwing away what Andrea has spent her whole life searching for. So what if she picks up Holly's castaway husband? Marissa has more than her fair share of challenges - a gay, rebellious teenage son; a terminally ill daughter; and a husband who buries himself in his work. As one woman's marriage unravels, another's rekindles. As one woman's family comes apart at the seams, another's reconfigures into something bigger and better. In this story of connections and disconnections, one woman's up is another one's down, and all of them will learn the meaning of friendship, betrayal, and forgiveness.